Systemic Corticosteroids in the Perioperative Management of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)

Inclusion Criteria: * Adult patients (ages 18-80) with a diagnosis of chronic rhinosinusitis without nasal polyps (CRSsNP) that have failed a 6 week trial of maximal medical therapy and have elected to undergo endoscopic sinus surgery will be offered enrollment in this study. * Diagnosis of chronic rhinosinusitis (CRS) is based on the European Position on Rhinosinusitis (EPOS) 2012 guidelines. * These include a greater than 12 week history of inflammation of the nose or paranasal sinuses characterized by at least 2 symptoms. * These symptoms must include at least one of the following: * nasal obstruction * rhinorrhea * postnasal drip. * Additional symptoms can include facial pain/pressure or anosmia/hyposmia. * These symptoms must be supplemented by either endoscopic signs of disease or characteristic CT changes. * The presence or absence of nasal polyps defines the subtype (with polyps: CRSwNP; without polyps: CRSsNP). Exclusion Criteria: * Patients will be excluded if they have nasal polyps or suspected allergic fungal rhinosinusitis (AFRS) based on classic endoscopy and CT findings. * Additionally, patients with known immunocompromise or mucociliary disorders will be excluded. * Patients that received oral corticosteroids within 6 weeks prior to the planned surgery will also be excluded.