Pregabalin Compared to Gabapentin for Pain Control in Lumbar Disc Surgery

Phase 3CompletedNCT02120703

Aga Khan University78 enrolled

Overview

Pregabalin is claimed to have superior analgesic effect at lower doses and better pharmacological profile as compared to gabapentin esp. in perioperative pain control after major surgeries like intervertebral disc surgery. The investigators found that pregabalin is equivalent to gabapentin for relief of post-operative pain at a lower dose in patients undergoing intervertebral disc surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Intervertebral Disc Prolapse

Interventions

PregabalinDRUG

Pregablin 75 mg per oral two times a day

GabapentinDRUG

Gabapentin 200 mg twice daily per oral

Eligibility

Sex: ALLMin age: 30 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 30-60 years age * Any gender * elective micro discectomy for intervertebral disc prolapse Exclusion Criteria: 1. micro discectomy at two or more vertebral levels, 2. Instrumentation i.e. pedicle screw fixation, hooks etc., 3. history of steroids or alcohol use, 4. Multiple co-morbids i.e. renal failure, chronic liver disease, 5. use of anticonvulsant drugs, 6. Spinal deformity, 7. Obesity (BMI \>30), 8) inability to understand and respond VAS and 9\) patients with known allergy to GABA analogues.

Locations (1)

The Aga Khan University Hospital

Karachi, Sindh, Pakistan

Outcomes

Primary Outcomes

Pain

Pain measurement using Visual Analogue Score at 24 hours and 7th day of surgery

Time frame: 7 days

Data from ClinicalTrials.gov

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