A Randomised Trial of Sertraline, Cognitive Behaviour Therapy & Combined Therapy for Postnatal Depression

Inclusion Criteria: * Women with an infant \> 2 months and \< 8 months of age * Infant born after a full-term pregnancy * Infant born with no congenital abnormalities * Diagnosis of depression with postnatal onset according to the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV). Exclusion Criteria: * positive serum pregnancy test; * concurrent psychiatric disorder (excepting co-morbid anxiety); * recent history of antidepressant usage (within the last month); * history of major allergy or drug allergy; * history of substance abuse; * prior non-response to sertraline, or prior non-response to adequate trials of two selective serotonin reuptake inhibitors (SSRIs); * predisposition to headache, migraine or nausea; * tobacco habit in excess of 10 cigarettes per day; * caffeine consumption in excess of 6 cups of coffee/tea or cola-flavoured drinks per day; * ongoing dental work; * extreme levels of depression (psychotic); * suicidal intent; * participation in any medical trial within the previous three months;