Phase I Study of Chiauranib in Patients With Advanced Solid Tumors

Inclusion Criteria: 1. Histological or cytological confirmation of advanced solid tumor, including non-small cell lung cancer, colorectal cancer, ovarian cancer, renal cell carcinoma, gastrointestinal stromal tumor, gastric cancer, et al; 2. Patients with advanced solid tumors refractory to standard therapy or for which no standard therapy exists; 3. Body mass index (BMI) is between 18 and 28; 4. Age: 18\~65 years; 5. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1; 6. Laboratory criteria are as follows: 1. Complete blood count: hemoglobin (Hb) ≥100g/L (no blood transfusion within 14 days); absolute neutrophil count (ANC) ≥1.5×109/L ; platelets \>=100×109/L 2. Biochemistry test: serum creatinine \<=1.5×upper limit of normal (ULN); total bilirubin≦1.5×ULN; alanine aminotransferase / aspartate aminotransferase≦1.5×ULN; fasting triglyceride (TG) \<= 3.0 mmol/L; total cholesterol \<= 7.75 mmol/L 3. Coagulation test: International Normalized Ratio (INR) \< 1.5 7. Women of child-bearing potential should be non-lactating patients, and must agree to use effective contraceptive methods prior to study entry, during study participation, and up to 6 months following completion of therapy. A serum or urine pregnancy test within 7 days before enrollment must be negative; Men must agree to use effective contraceptive methods during study participation and up to 6 months following completion of therapy; 8. Willingness to sign a written informed consent document Exclusion Criteria: 1. Life expectation \< 3 months; 2. Subjects received anti-cancer therapy (including chemotherapy, radiotherapy, targeted therapy and endocrine therapy, et al) within 4 weeks prior to study entry; Subjects received nitrosoureas or mitomycin chemotherapy within 6 weeks prior to study entry; 3. Have uncontrolled or significant cardiovascular disease, including: 1. Myocardial infarction (\< the last 12 months) 2. Uncontrolled angina (\< the last 6 months) 3. Congestive heart failure (\< the last 6 months), or Left Ventricular Ejection Fraction (LVEF) \< 50% prior to study entry 4. History of any significant ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, or TdP) 5. History of significant QT interval prolongation, or Corrected QT Interval (QTc) \> 450 ms prior to study entry 6. History of cerebrovascular accident 7. Symptomatic coronary heart disease requiring treatment with agents 8. Uncontrolled hypertension (\> 140/90 mmHg) by single agent; 4. Have active bleeding , current thrombotic disease, or patients with bleeding potential receiving anticoagulation therapy; 5. History of deep vein thrombosis or pulmonary embolism; 6. Have unsolved toxicities (\> grade 1) from prior anti-cancer therapy; 7. Have clinical significant gastrointestinal abnormality, e.g., unable to swallow, chronic diarrhea, ileus, that would impair the ingestion,transportation or absorption of oral agents, or patients undergone gastrectomy; 8. Have symptomatic brain metastasis; 9. History of organ transplantation; 10. Proteinuria positive; 11. Congenital or acquired immunodeficiency, active infections; 12. Any mental or cognitive disorder, that would impair the ability to understand the informed consent document or the operation and compliance of study; 13. Any other condition which is inappropriate for the study in the opinion of the investigators.