The purpose of this study is to understand the differences in how patients with heart failure respond to exercise training compared to patients with heart failure and type 2 diabetes.
The investigators will measure exercise capacity in patients with heart failure or heart failure plus type 2 diabetes prior to and following a 12-week exercise training program (5d/wk, 30 min/d, 60-75% VO2max) to determine whether improvements in exercise capacity in response to exercise training are mitigated in patients with combined heart failure plus type 2 diabetes.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
12 weeks of supervised aerobic exercise training
Duke University Medical Center
Durham, North Carolina, United States
exercise capacity
measured as peak oxygen consumption as well as treadmill time to exhaustion, also known as cardiopulmonary fitness
Time frame: baseline, 12 weeks
flow-mediated dilation
brachial artery flow-mediated dilation
Time frame: baseline, 12 weeks
nitrite flux during exercise
changes in plasma nitrite during exercise
Time frame: baseline, 12 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.