A Micro/Nano Device for Exhaled Breath Analysis

University of Louisville728 enrolled

Overview

Use of a microfabricated silicon device to concentrate ultra trace volatile organic compounds (VOCs) in human exhaled breath for quantitative analysis of VOCs.

Will use Fourier Transform Mass Spectrometry (FT-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) to analyze concentrated VOCs. The purpose of this study is to search for disease-related markers in the breath in subjects with known or suspected lung or other cancer, or pulmonary disease.

Study Type

OBSERVATIONAL

Enrollment

728

Conditions

Lung Cancer Pulmonary Disease

Eligibility

Sex: ALLMin age: 20 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * For controlled (healthy) subjects - we are seeking persons who do not have a known history of cancer or pulmonary disease. * Both smokers and nonsmokers are invited to participate as control subjects. * For experimental subjects, we are seeking persons with pulmonary disease but no known history of cancer, as identified by the investigators during routine clinic or office visits. * Additionally for experimental subjects, we are seeking persons with known or suspected lung or other cancers, as identified by the investigators during routine clinic or office visits. Exclusion Criteria:

Locations (1)

James Graham Brown Cancer Center-University of Louisville

Louisville, Kentucky, United States

Outcomes

Primary Outcomes

Detection of disease related markers (biomarkers) from concentrated volatile organic compounds in breath samples

The concentrated volatile organic compounds in exhaled breath samples will be analyzed by statistical software for search for disease related markers (biomarkers).

Time frame: 1 day (After sample collection)

Data from ClinicalTrials.gov

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