HOT: HIPEC in Ovarian Cancer as Initial Treatment

Inclusion Criteria: * Clinical presentation of ovarian, fallopian tube or primary peritoneal cancer * Stage III/IV disease * No prior treatment or significant surgery for the management of ovarian, fallopian tube, or primary peritoneal carcinoma; History of laparoscopic procedures to obtain diagnostic biopsies will be permitted in the study * Histological confirmation * Eastern Cooperative Oncology Group performance status 0-2 or Karnofsky performance status ≥ 70% * ≤1 cm residual disease at the completion of the cytoreductive surgery (GOG criteria for optimally cytoreduction) * Bone marrow function: 1. Absolute neutrophil count (ANC) ≥1,000/mm3 2. Platelets ≥100,000/mm3 3. Hemoglobin ≥ 8.5 g/dL * Renal function: 1\) Creatinine ≤1.5 times the upper limit of normal or a calculated creatinine clearance ≥60ml/min * Hepatic function: 1. Bilirubin ≤1.5 times upper limit of normal 2. Alanine aminotransferase (ALT) ≤3 times upper limit of normal 3. Aspartate aminotransferase (AST) ≤3 times upper limit of normal * Blood coagulation parameters: 1. Prothrombin time (PT) with International Normalized Ratio of ≤1.5 and a partial prothrombin time (PTT) ≤1.5 times upper limit of normal 2. For patients on full dose warfarin, in range International Normalized Ratio (usually between 2 and 3) and 3. Partial prothrombin time (PTT) \<1.2 times upper limit of normal 4. Candidate for administration of postoperative standard platinum-based combination systemic chemotherapy (adequate bone marrow, renal, hepatic function, and blood coagulation parameters) Exclusion Criteria: * Any prior treatment modality for the diagnosis of ovarian, fallopian tube, or primary peritoneal cancerPrior surgical attempt of cytoreductive surgery * Stage I/II disease * Presence of other invasive malignancies or evidence of other cancer within the past 3 years * Known active acute hepatitis and confirmed diagnosis of HIV * Active systemic infection that requires use of parenteral antibiotics * History of acute coronary syndromes (ACS), within the last 6 months, according to AHA definitions * New York Heart Association (NYHA) Class II or higher congestive heart failure according to American Heart Association (AHA) definitions * Canadian Cardiovascular Society (CCS) Class II or higher angina grade according to AHA definitions * Uncontrolled hypertension defined as \> 140/90 and not cleared for surgery at time of consent by cardiologist * History of cerebral artery disease and prior stroke according to AHA definitions in the last 6 months * Renal insufficiency with serum creatinine level ≥1.5 times the upper limit of normal or calculated creatinine clearance \<60 ml/min * Patients with concurrent severe medical problems unrelated to malignancy that will preclude compliance with the study or places at an unacceptable risk for participation in the study determinate by study investigators * Pregnant women are excluded from this study because carboplatin is category D agent with the potential of teratogenic effects. Due to potential risk for adverse events in nursing infants secondary to treatment of the mother with carboplatin, breastfeeding should be discontinued * Life expectancy of \< 12 weeks