Prospective association study to analyse perioperative patients' outcome. Outcome comprises intraoperative and postoperative complications e.g. cardio-vascular events, allergic reactions, Possible variables which might have on influence: patient- and surgery-related data, patients' genetic background etc.
Background Anesthesia and surgery are related to unwanted adverse events, side effects and postoperative discomfort. Whereas severe complications like cardiovascular events are rare, postoperative side effects like nausea and vomiting, pain, long-lasting pain and pain related interference of daily activities are frequent. The question arises which patient is at specific risk for this sequelae. Pre-exiting predisposing factors (e.g. patients' genetic background), surgery and anesthesia related variables (drugs, techniques administered for anesthesia and analgesia) as well as psychological and social factors might influence the outcome. In this prospective association study these variables will be investigated in a well-described patient cohort presenting for elective surgery. Objective The aim of this study is to associate perioperative and postoperative complications and side effects as well as long-term outcome after surgery to patient- and surgery-related variables, including genetic variants. Methods Prospective association study performed in two independent patient cohorts.
Study Type
OBSERVATIONAL
Enrollment
20,000
Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern
Bern, Switzerland
RECRUITINGPostoperative nausea and vomiting (PONV)
Percent of patients with no PONV, medium PONV and severe PONV PONV outcome measured by a composite score: number of episodes of vomiting + severity of nausea (NRS score) + need for antiemetic treatment Patients with no PONV are compared to those with intermediate and severe PONV
Time frame: Up to 48 hours after surgery
Pain related impairment after surgery
Measured by the International Pain Outcomes Questionnaire
Time frame: up to 2 days after surgery
Pain related impairment of patients with chronic pain after surgery versus patients without chronic pain after surgery
Measured by the Brief Pain Inventory (BPI)
Time frame: up to one year after surgery
Cardio-vascular events after surgery
Measured by a score for major adverse cardiac events (MACE)
Time frame: Up to 30 days after surgery
Pain related impairment of patients with chronic neuropathic pain (DN4 positive) after surgery versus patients without neuropathic pain after surgery
Measured by the Brief Pain Inventory (BPI)
Time frame: up to one year after surgery
What influences pain related impairment after bariatric surgery
Measurement of patient reported outcome by the BPI (Brief Pain Inventory).
Time frame: up to 1 year after surgery
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