Adjuvant Radiotherapy Comparing TACE for Curative HCC

Inclusion Criteria: * Age 18-75 years * Diagnosis of HCC was confirmed by histopathological examination of surgical samples in all patients * Patients have Child-Pugh A liver function and undergo potentially curative hepatic resection * Patients with risk factors for recurrence (tumor size \>5 cm, multiple nodules, vascular invasion, absence of tumor capsule, poorly differentiated tumor, and narrow resection margin) * No previous treatment of HCC except liver resection * No evidence of metastasis to the lymph nodes and/or distant metastases on the basis of preoperative imaging results and perioperative findings * No malignancy other than HCC for 5 years prior to the initial HCC treatment * No imaging evidence of invasion into the major portal/hepatic vein branches * No history of encephalopathy, ascites refractory to diuretics or variceal bleeding Exclusion Criteria: * History of cardiac disease: * congestive heart failure \> New York Heart Association (NYHA) class 2; * active coronary artery disease (myocardial infarction more than 6 months prior to study entry is permitted); * cardiac arrhythmias requiring anti-arrhythmic therapy other than beta blockers, calcium channel blocker or digoxin; or * uncontrolled hypertension (failure of diastolic blood pressure to fall below 90 mmHg, despite the use of 3 antihypertensive drugs). * Active clinically serious infections ( \> grade 2 National Cancer Institute \[NCI\]-Common Terminology Criteria for Adverse Events \[CTCAE\] version 3.0) * Known history of human immunodeficiency virus (HIV) infection * Known Central Nervous System tumors including metastatic brain disease * Patients with clinically significant gastrointestinal bleeding within 30 days prior to study entry * History of organ allograft * Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results * Known or suspected allergy to the investigational agent or any agent given in association with this trial * Any condition that is unstable or which could jeopardize the safety of the patient and his/her compliance in the study * Pregnant or breast-feeding patients. Women of childbearing potential must have a negative pregnancy test performed within seven days prior to the start of study drug. Both men and women enrolled in this trial must use adequate barrier birth control measures during the course of the trial. * Excluded therapies and medications, previous and concomitant: * Prior use of any systemic anti-cancer treatment for HCC, eg. chemotherapy, immunotherapy or hormonal therapy (except that hormonal therapy for supportive care is permitted). Antiviral treatment is allowed, however interferon therapy must be stopped at least 4 weeks prior randomization. * Prior use of systemic investigational agents for HCC * Autologous bone marrow transplant or stem cell rescue within four months of start of study drug