Efficacy of a Depigmented Extract of Phleum in Local Allergic Rhinitis

Inclusion Criteria: * Local allergic rhinitis with sensitization to grass pollen * Skin prick test and serum specific IgE negative to grass pollen. * Positive Nasal allergen provocation test (NAPT) to grass pollen and/or positive nasal specific IgE to grass pollen. * Written informed consent Exclusion Criteria: * Immunological diseases * Heart diseases that limit the use of adrenaline. For example, severe hypertension or treatment with beta-blockers. * Treatment with beta-blockers * Severe psychological disorders * Severe atopic dermatitis * FEV1 \< 70% of reference value after treatment * Hypersensitivity or intolerance to excipients and / or medication trial. * Failure to adequately perform diagnostic tests or treatment. * Sensitization to other allergens (perennial or seasonal) with clinical relevance for the subject and that may interfere in the evaluation of the response. * Immunotherapy in the 5 years prior to their inclusion in the study. * Pregnant women or at risk of pregnancy and lactating women.