Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function. For this purpose we measure capillary oxygen concentration and vascular. Vascular function is assessed by flow-mediated dilation oft he brachial artery, forearm blood flow and laser doppler perfusion imaging. We hypothesize that hypoxemia leads to impaired vascular function.
Study Type
OBSERVATIONAL
Enrollment
38
Division of Cardiology, Pulmonary Disease and Vascular Medicine
Düsseldorf, Germany
Flow-mediated dilation of the brachial artery
Time frame: Baseline
Forearm blood flow
Time frame: Baseline
Laser doppler perfusion
Time frame: Baseline
Intima-media thickness of the brachial artery
Time frame: Baseline
Fractional diameter change of the brachial artery
Time frame: Baseline
Endothelium-independent vasodilation of the brachial artery
Time frame: Baseline
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