Gabapentin pretreatment may reduce hyperalgesia occurring at the second surgery in serial, bilateral cataract surgery.
Hyperalgesia occurring at the second operation in bilateral eye surgery is well known, and mechanism of central sensitization might be involved. Gabapentin is known to lower the effect of central sensitization, and its effect on acute postoperative pain has been reported. Therefore, pretreatment of gabapentin after first operation may reduce the pain at second operation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
70
100 mg tid of gabapentin is prescribed to the patient for 1 week after the first eye surgery
the same regimen of placebo drug is prescribed to the patient for 1 week after the first eye surgery
Seoul National University Hospital
Seoul, South Korea
RECRUITINGproportion of subjects who answer that "pain was greater" in the second eye surgery
Time frame: Intra operative (pain while fluid injection to anterior chamber)
perioperative pain
evaluation of overall perioperative pain
Time frame: end of surgery, post-op 1hr at PACU, at out-patient ward, post-op 1 day
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