The purpose of this study is to determine if consumption of bagels made with resistant starch for 8 weeks can improve markers of type 2 diabetes, colon cancer and satiety in adults.
Using a randomized, double-blind crossover study design, we will determine the effect of consuming bagels made with resistant starch daily for 8-weeks can reduce the risk of type 2 diabetes and colon cancer in an adults who are at an increased risk for type 2 diabetes. Additionally, we will compare the satiating effect of these bagels to that of a standard bagel.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
25
In a randomized crossover fashion, participants will consume bagels that are made with either high-resistant starch or standard wheat flour, daily for a period of 8 weeks, with a 4 week washout period.
Human Nutraceutical Research Unit
Guelph, Ontario, Canada
Fasting and postprandial blood glucose
Blood glucose will be measured in the fasting state and postprandially (during a 3-hour oral glucose tolerance test) on the first and last study days of both treatment periods.
Time frame: up to day 57 of both treatment periods
Fasting and postprandial insulin
Circulating insulin will be measured in the fasting state and postprandially (during a 3-hour oral glucose tolerance test) on the first and last study days of both treatment periods.
Time frame: up to day 57 of both treatment periods
HbA1c
HbA1c (glycated haemoglobin) will be measured from fasting blood drawn on days 1 and 57 of both treatment periods.
Time frame: Day 1 and 57 of both treatment periods
Calculated insulin sensitivity and beta-cell function
Data will be used from 3-hour oral glucose tolerance tests performed on days 1 and 57 of both treatment periods.
Time frame: Days 1 and 57 of both treatment periods
Satiety-producing effect
After study bagel consumption as part of a standard breakfast, questionnaires will be used to quantify subjective measures of satiety, and weighted food records will be used to objectively measure food intake for the rest of the day.
Time frame: Day 2,3 or 4 of both treatment periods
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