Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers

Inclusion Criteria: * Ankle Brachial Pressure Index (ABI) ≥ 0.80 * Venous insufficiency confirmed by duplex Doppler ultrasound * Presence of a venous leg ulcer, unresponsive to Standard of Care treatment for at least 4 weeks and between ≥ 1 cm2 and ≤ 17.1 cm2 at screening; and between ≥ 1 cm2 and ≤ 12cm2 at the Baseline Visit Exclusion Criteria: * Target Ulcer has decreased \>30% in size from Screening to Baseline * Documented history of osteomyelitis at the Target Ulcer location within 6 months preceding the Baseline Visit. * Patients who are unable to tolerate multi-layer compression therapy. * Ulcer, which in the opinion of the Investigator is suspicious for cancer. * Any malignancy within the past 5 years, excluding successfully treated basal cell carcinoma or squamous cell carcinoma without evidence of metastases. * History of radiation at the Target Ulcer site in previous 12 months prior to Baseline Visit. * Patients with clinically significant claudication * Current sepsis * Patients with known history of significantly compromised immunity for any reason including radiation therapy, chemotherapy or HIV