The purpose of this study is to determine whether intracoronary selective thrombolysis are more effective than tirofiban on the coronary flow during primary percutaneous coronary intervention for the acute myocardial infarction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
362
20mg intracoronary bolus infusion using selective catheter during PCI
10ug/kg intracoronary bolus infusion using selective catheter during PCI
intracoronary bolus infusion using selective catheter during PCI
Department of Cardiology, Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, China
Coronary flow using corrected Thrombolysis In Myocardial Infarction Frame Count (cTFC)
Time frame: At the end of Percutaneous Coronary Intervention procedure
ST segment resolution in ECG
Time frame: 3 hours post PCI procedure
peak troponin T level
Time frame: in the 7 days post PCI procedure
plasma N terminal-proBNP levels
Time frame: 1 and 30 days post PCI procedure
infarction area confirmed by SPECT
Time frame: 30 days post PCI
incidence of major adverse cardiac events (MACE) defined as the composite of death, myocardial infarction and target vessel revascularization
Time frame: 30 days post PCI
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