Prevalence of Vertebral Fractures in HIV Infected Patients Older Than 50 Years

Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal130 enrolled

Overview

Prospective cohort study to determine the prevalence of vertebral fractures in HIV infected patients older than 50 years.

To determine the prevalence of asymptomatic vertebral fractures in HIV patients older than 50 years, and the risk of fracture during a follow up of 2 years, according to bone mineral density at inclusion, the level of serum bone biomarkers, and the presence of secondary factors such as hypovitaminosis D or/and secondary hyperparathyroidism.

Study Type

OBSERVATIONAL

Enrollment

130

Conditions

Vertebral Fractures

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age above 50 years * HIV infection Exclusion Criteria: * Pregnancy * Receiving corticosteroids or antiresorptive therapy

Locations (1)

Ramon y Cajal Hospital

Madrid, Spain

Outcomes

Primary Outcomes

Prevalence of vertebral fractures in HIV patients older than 50 years

To determine by lumbar and thoracic x ray the presence of vertebral fractures and the changes in vertebral form or size, according to Genant methods

Time frame: 2 years

Secondary Outcomes

Risk of vertebral alteration according to bone mineral density and serum biomarkers

To determine the relationships of vertebral alterations with bone mineral density by dual X-ray absorptiometry

Time frame: 2 years

Vertebral alterations during follow up

To determine the emergence of vertebral alterations during 2 years of follow up according to bone mineral density, bone biomarkers (osteocalcin, beta-crosslaps), and vitamin D/parathyroid hormone (PTH) status.

Time frame: 2 years

Data from ClinicalTrials.gov

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