This research is being done to better understand how to help patients who are not receiving enough relief from opioid prescription medications for chronic non-cancer pain. Opioids are a group of medications that includes morphine, oxycodone-, hydrocodone-, etc. These medications are also called narcotics. Research has shown that patients not benefiting from their opioid prescription medication often feel better when they stop taking it. However, stopping or reducing pain medications can be a difficult transition. Although they do not have much benefit from their medication, many patients are afraid to stop because they feel these medications are the only things giving them a bit of relief. Different strategies can be used to help patients through the period of tapering and it is not clear which one is best. The investigators will test a specific approach used during regular care in the clinic: cognitive therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
6
10- weekly 1h30 group sessions including psychoeducation and group discussions on pain, pain coping, opioid mechanisms, and relationship between mood, sleep, stress and pain.
Massachusetts General Hospital Center for Pain Medicine
Boston, Massachusetts, United States
Number of participants with daily opioid dose below 50% of initial dose
successful taper
Time frame: 10 weeks
signs of hyperalgesia on Quantitative Sensory Testing (QST)
evolution of QST scores following taper
Time frame: 10 weeks
signs of hyperalgesia on QST
at 3 months follow-up from taper, evolution of hyperalgesia
Time frame: 24 weeks
number of patients who are not prescribed opioids on daily basis ("full taper")
described as not taking opioids on a daily basis
Time frame: within 10 weeks
Time to reach >50% taper.
time to reach 50% taper will eb recorded in all individuals
Time frame: 24 weeks
Pain scores (Brief Pain Inventory)
Time frame: 10 and 24 weeks
Absolute opioid dose reduction
calculation of absolute dose reduction
Time frame: 10 and 24 weeks
Functional Impairment
Brief Pain Inventory Interference scale and National Institute of Health Patient Reported Outcomes Measurement Information System (PROMIS) scale
Time frame: 10 and 24 weeks
Number of patients who reach a full taper amongst those having not reached this outcome at 10 weeks.
Time frame: 24 weeks
Anxiety and depression (HADS).
Time frame: 10 and 24 weeks
Withdrawal (COWS measure).
Time frame: 10 and 24 weeks
Hedonic tone (SHAPS).
Time frame: 10 and 24 weeks
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