Cross-sectional Study of Use of Speckle Method in Early Diagnosis of Cardiovascular Dysfunction

University of Roma La Sapienza700 enrolled

Overview

Speckle tracking (STE) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (SR). It is demonstrated that these parameters provide important insights into systolic and diastolic function, ischaemia, myocardial mechanics and many other pathophysiological processes of the heart. In this preliminary study, we investigated the role of STE in detection of early ventricular dysfunction in patients with Sjogren Syndrome, focusing on cardiorespiratory fitness.

Study Type

OBSERVATIONAL

Enrollment

700

Conditions

Sjogren Syndrome

Interventions

Speckle tracking echocardiographyPROCEDURE

Eligibility

Sex: ALLMin age: 40 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of Sjogren Syndrome Exclusion Criteria: * previous cardiovascular events * unstable angina * stroke * diagnosis of heart failure * incapacity to provide an informed consent

Locations (2)

Galeazzi IRCCS of Milan

Milan, Italy, Italy

Sapienza University

Rome, Italy

Outcomes

Primary Outcomes

Longitudinal Myocardial Strain reduction in Sjogren Patients

Longitudinal Myocardial Strain reduction could be an early marker of cardiac dysfunction in patients with Sjogren Syndrome, significantly better than common measurement (such as ejection fraction)

Time frame: Baseline, 24 weeks

Secondary Outcomes

Association between 6minute-walking-test and Longitudinal strain reduction

Longitudinal strain reduction could be linked to decrease in cardiorespiratory fitness, especially in 6-minute-walking-test

Time frame: baseline, 24 weeks

Data from ClinicalTrials.gov

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