Preload Dependency by Impedance Cardiography After Cardiac Surgery

University Hospital, Strasbourg, France65 enrolled

Overview

The primary purpose of this study is to investigate wether the measure of stroke volume (SV) variations by impedance cardiography during passive leg raising (PLR) can reliably predict preload dependency after cardiac surgery, in comparison to a reference parameter : velocity time integral (VTI) variation measured by transthoracical echocardiography.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiac Surgery With Extracorporeal Circulation

Interventions

Impedance cardiography Physioflow ®DEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Men or women over 18 years * Affiliated to a social protection * Signed written consent * Informed about the results of the medical visit * All type of cardiac surgery with extracorporeal circulation performed at University Hospital of Strasbourg * Sedated and under mechanical ventilation Exclusion Criteria: * Cardiac arrhythmia * Contraindication to PLR maneuver * Exclusion period due to inclusion in a previous or ongoing study * Impossibility to provide enlightened information * Patient deprived of liberty, under judicial protection, trusteeship or guardianship * Pregnancy, lactation

Locations (1)

Service d'Anesthésiologie, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg

Strasbourg, France

Outcomes

Primary Outcomes

Area under ROC curve comparing SV variation (impedance cardiography) and VTI variation after PLR

Patients classified as responders and non responders to PLR : VTI variation ≥ 12% or \< 12%

Time frame: Within the 6 first hours after cardiac surgery

Secondary Outcomes

Variation of central veinous pressure, left auricular pressure and left ventricular filling pressures after PLR (ROC curves, correlation tests)

Time frame: Within the 6 first hours after cardiac surgery

Respiratory variation of inferior vena cava

Time frame: Within the 6 first hours after cardiac surgery

Data from ClinicalTrials.gov

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