The purpose of this study is to compare the difference of incidence of postoperative delirium between patients received general anesthesia guided by Bispectral index (BIS) and patients received general anesthesia using standard technique.
General anesthesia is one of precipitating factor of postoperative delirium which Its mechanism is still unknown. General anesthesia can affect on pattern of electroencephalograph. Previous studies showed that patients received BIS guided anesthesia could wake up faster, earlier extubation and stay in recovery room shorter compared to standard general anesthesia. Optimized level of anesthesia by BIS could reduce cognitive dysfunction in elderly patients and reduce biological marker of brain injury. Therefore, the investigators hypothesized that adjustment of general anesthesia by BIS guided could protect central nervous system and reduce incidence of postoperative delirium.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
140
Comparisons of incidence of postoperative delirium.
Department of Anesthesiology, Faculty of Medicine, Chiang Mai University
Maung, Chiang Mai, Thailand
RECRUITINGNumber of patients have postoperative delirium
Assess postoperative delirium by using Confusion Assessment Method for intensive care unit (CAM-ICU) at recovery room and Confusion Assessment Method at inpatient ward.
Time frame: Participants will be followed during the duration of hospital stay, an expected avarage of two weeks.
Number of patients with impaired cognitive function
Assessed postoperative cognitive function by using Mini-Mental State Examination and Montreal Cognitive Assessment (MoCA) .
Time frame: Up to 6 months
Time to recovery
Time between end of anesthesia and eye opening, spontaneous breathing, and extubation.
Time frame: The end of surgery
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