The aim of this study is to distinguish possible differences in frequency of delirium after Volatile Induction and Maintenance of Anesthesia and Total Intravenous Anesthesia in case of undeliberate cerebral desaturation during non-cardiac surgery.
The aim of the present study is to investigate whether in non-cardiac surgery the frequency of POD after intraoperative undeliberate cerebral saturation could be modulated by the choice of the anesthetic strategy (Volatile Induction and Maintenance of Anesthesia \[VIMA\] and Total Intravenous Anesthesia \[TIVA\]). Based on our previous data we hypothesized that incidence of POD would be lower with VIMA compared to TIVA.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
130
Induction of anesthesia: fentanyl 2 µg kg-1 and a bolus inhalation of 8% sevoflurane in an 8 L.min-1 fresh gas flow. Anesthesia maintenance: 1 minimal alveolar concentration (MAC) sevoflurane at a low fresh gas flow of 0.6-0.8 L min-1 in a 60% air-oxygen mixture supplemented with boluses of fentanyl.
Induction of anesthesia: propofol 2 mg kg-1 and fentanyl 4 µg kg-1. Maintenance of anesthesia: infusion of propofol 8 mg kg-1 h-1 and boluses of fentanyl 3 µg kg-1.
Medical center of the Main Administration for Service to the Diplomatic Corps
Moscow, Russia
RECRUITINGRegional Cerebral Oxygenation (rSO2)
Time frame: Continued the entire surgery
Peripheral tissue oxygen saturation (SpO2)
Time frame: Continued the entire surgery
Non-invasive blood pressure (NIBP)
Time frame: Continued the entire surgery
Number of Incidences of postoperative delirium (POD)
Applying the Confusion Assessment Method for the ICU (CAM-ICU)
Time frame: Baseline, 24h and 48h after surgery
Plasma concentration of S100b protein
S100b protein is the neuronal injury marker
Time frame: Baseline, 24h and 48h after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.