The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Induction

First Hospital of China Medical University45 enrolled

Overview

It is a prospective, randomized, placebo-controlled study to investigate the effect of TEA with different block level on propofol concentration during general anesthesia induction.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Target Controlled Infusion (TCI)Thoracic Epidural Anesthesia Block Level Gastrointestinal Surgery

Interventions

1% lidocaineDRUG

epidural anesthesia with 1% lidocaine 10ml before propofol TCI

2% lidocaineDRUG

epidural anesthesia with 2% lidocaine 5ml before propofol TCI

0.9% normal salineDRUG

epidural anesthesia with 0.9% normal saline 5ml before propofol TCI

Eligibility

Sex: ALLMin age: 40 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists (ASA) I-II physical status, * aged 40-60 yr, * BMI 19-25 kg/m2, * undergoing elective gastrointestinal surgery Exclusion Criteria: * patients with cardiovascular or neurological disease, drug or alcohol abuse and absolute contraindications for neuraxial blockade.

Locations (1)

Jun Wang

Shenyang, Liaoning, China

Outcomes

Primary Outcomes

The Effect-site Concentration of Propofol

The effect-site concentration of propofol when loss of consciousness during propofol target-controlled infusing(TCI) induction of anesthesia.

Time frame: The participants will be followed for the duration of anesthesia induction, an expected average of half an hour

Secondary Outcomes

The Bispectral Index

The bispectral index (BIS) of each patient will be recorded at four different time points,as follows, baseline(the awake phase before epidural anesthesia),10 mins after epidural anesthesia, 20 mins after epidural anesthesia, loss of consciousness(when the participants are lost eyelash reflex during propofol TCI induction of anesthesia). BIS values varies from 0 to 100(0, no cerebral activity; 40 to 60, general anesthesia; 60 to 85, sedated; 85 to 100, awake).

Time frame: The participants will be followed for the duration of anesthesia induction, an expected average of half an hour

The Mean Blood Pressure

The mean arterial pressure of each patient will be recorded at four different time points, as follows, baseline(the awake phase before epidural anesthesia), 10 mins after epidural anesthesia, 20 mins after epidural anesthesia, loss of consciousness(when the participants are lost eyelash reflex during propofol TCI induction of anesthesia).

Time frame: The participants will be followed for the duration of anesthesia induction, an expected average of half an hour

The Heart Rate

The heart rate of each patient will be recorded at three different four points, as follows, baseline(the awake phase before epidural anesthesia), 10mins after epidural anesthesia, 20 mins after epidural anesthesia, loss of consciousness(when the participants are lost eyelash reflex during propofol TCI induction of anesthesia).

Time frame: The participants will be followed for the duration of anesthesia induction, an expected average of half an hour

Data from ClinicalTrials.gov

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