The intensive arterial pressure control in acute coronary syndrome (ACS) during the first 24 hours can improve the prognosis in the short and long term. the study compare two treatment strategies (standard and intensive treatment) to assess their efficacy and safety in the treatment of acute coronary syndrome.
Acute coronary syndrome is often associated with arterial pressure elevation which are deleterious for the heart and needs urgent intervention to lower the blood pressure to the required values, however there is no clear recommendations concerning the treatment intensity in this situation. The investigators know that high arterial pressure increases the oxygen myocardial consumption and it is deleterious in acute coronary syndrome, so , it is logical to reduce intensively this pressure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
1,500
administration of continuous intravenous isosorbide dinitrate to obtain a SBP between 110 and 120 mmHg. After 2 hours from the start of treatment and if the blood pressure goal is not achieved, labetalol is used
university of Monastir
Monastir, Tunisia
mortality
1-year death rate
Time frame: 12 months
major cardiovascular events (MACE)
1-year MACE rate
Time frame: 12months
combined mortality and MACE rate
combined mortality and MACE rate at one year.
Time frame: 1 year
troponin change
troponin change between baseline and 24 hour after
Time frame: 24 hours after baseline measurement
Adverse events
Severe hypotension
Time frame: 24 hours after start of protocol intervention
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