Effects of Exercise Training on Cardiovascular Health in Middle-aged Women

University of Copenhagen36 enrolled

Overview

The hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Menopause Cardiac Function Impaired Cardiovascular Diseases Blood Platelet Disorders Metabolic Diseases

Interventions

SpinningBEHAVIORAL

After the baseline studies the pre and postmenopausal women will be randomized to spinning training groups and the intervention will last for 3 months. The spinning group will spin three times per week under guidance of a trained instructor. The training is heart rate monitored.

Eligibility

Sex: FEMALEMin age: 45 YearsMax age: 57 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Premenopausal (45-53 years) OR postmenopausal 50-57 years * BMI\> 18.5 and \<30 * Sedentary (no regular physical activity the last 2 years) * Plasma measurements * Premenopausal: estradiol\> 0.20 nmol/l, Follicle stimulating hormone \< 22 IU/l and progesterone \>2.5 nmol/l * Postmenopausal: estradiol \< 0.20 nmol/l, Follicle stimulating hormone \> 22 IU/l and progesterone 0.3-2.5 nmol/l Exclusion Criteria: * Smoking * Excessive alcohol intake * Regular medication including hormone replacement treatment * Chronic disease

Locations (1)

University of Copenhagen

Copenhagen, Denmark

Outcomes

Primary Outcomes

Leg vascular function

Measurements of leg blood flow by ultrasound doppler during exercise and during femoral arterial infusion of vasodilators