Water exchange method has been shown to reduce medication requirement and pain experienced during colonoscopy. It may increase the adenoma detection rate (ADR). Water exchange provides salvage cleansing and the refractive index of water (n equals about 1.3) is larger than that of air, which creates optical distortion that likely contributes to objects appearing larger underwater, making smaller lesions easier to visualize and it may help draw attention to those smaller lesions during withdraw. These principles facilitate to the higher adenoma detection rate. There is a large number of literature on the adenoma detection rate during water exchange colonoscopy, but most studies have been conducted in only one centre, simple-size, and under sedation patients, the influence of adenoma detection rate under unsedation patients was unclear. The aim of this study is to compare the ADR of colonoscopy by using the water exchange method versus the conventional air method in unsedation patients in multiple centers in China.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
SINGLE
Enrollment
3,303
Colonoscopy will be performed without medications and aided by water infusion in-lieu of air insufflation during insertion of the colonoscope. The water infusion involves putting warm sterile water into the colon to open up the colon for advancement of the colonoscope until the end of the colon (cecum) is reached. The water is delivered through scope irrigation channel by an infusion pump equipped with a foot switch which will be controlled by the endoscopist. Infused water used to cleanse residual fecal matter will be suctioned as needed to clear the colonic lumen.
Chaoyang Hospital
Beijing, Beijing Municipality, China
General Hospital of Guangzhou Military Command
Guangzhou, Guangdong, China
Union Hospital of Tongji Medical college
Wuhan, Hubei, China
Xijing Hospital of Digestive Diseases
Xi'an, Shaanxi, China
Renji Hospital
Shanghai, Shanghai Municipality, China
First Teaching Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
Adenoma detection rate
The proportion of participants with at least one adenoma in each group
Time frame: up to one year
Pain Scores on the Visual Analog Scale
0 = no pain, to 10 = most severe pain
Time frame: up to one year
Cecal intubation success rate
Insertion of a colonoscope to the cecum
Time frame: up to one year
Cecum intubation time
Total time of colonoscope intubation from anus to cecum
Time frame: up to one year
Quality of Bowel Preparation
BBPS：cleanliness of each part of the colon: 0=unprepared colon segment with mucosa not seen because of solid stool that cannot be cleared; 1=portion of mucosa of the colon segment seen, but other areas of the colon segment not well seen because of staining, residual stool, and/or opaque liquid; 2=minor amount of residual staining, small fragments of stool and/or opaque liquid, but mucosa of colon segment seen well; 3=entire mucosa of colon segment seen well with no residual staining, small frag- ments of stool, or opaque liquid.
Time frame: up to one year
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