In this randomized, double-blind, placebo-controlled trial we plan to enrol 200 vitamin D deficient hypertensive patients. Our main objective is to evaluate whether vitamin D3 supplementation with 2,800 IU daily for 8 weeks has an effect on 24-hour systolic ambulatory blood pressure (ABP) compared to placebo. In addition, we also aim to evaluate whether vitamin D3 supplementation alters 24-hour diastolic ABP, pulse wave velocity, N-terminal-pro-brain natriuretic peptide (NT-pro-BNP), corrected QT interval (Bazett formula), renin, aldosterone, 24-hour urinary albumin excretion, HOMA-IR (HOmeostatic Model Assessment: Insulin Resistance), triglycerides and HDL-cholesterol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
200
The treatment group receives 2,800 IU vitamin D3 per day as oily drops (Oleovit D3, producer: Fresenius Kabi Austria, A-8055 Graz) for 8 weeks
Medical University of Graz
Graz, Austria
24-hour systolic ambulatory blood pressure
Time frame: 8 weeks
24-hour diastolic ambulatory blood pressure
Time frame: 8 weeks
N-terminal-pro-brain natriuretic peptide (NT-pro-BNP)
Time frame: 8 weeks
corrected QT interval (Bazett formula)
Time frame: 8 weeks
Renin
Plasma renin concentration
Time frame: 8 weeks
Aldosterone
Plasma aldosterone concentration
Time frame: 8 weeks
24-hour urinary albumin excretion
Time frame: 8 weeks
HOMA-IR
HOMA-IR (HOmeostatic Model Assessment: Insulin Resistance)
Time frame: 8 weeks
Triglycerides
Time frame: 8 weeks
HDL-cholesterol
Time frame: 8 weeks
Pulse wave velocity
Time frame: 8 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.