Multiple Dose-parallel-group Study of AMA0076 in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension

Inclusion Criteria: * Adults 30-85 years of age. * Diagnosis of either POAG or OHT in both eyes. * Not receiving medication for IOP, or able to stop such medication for a washout period and the duration of the study without significant risk of adverse consequences related to glaucomatous disease. * Elevated IOP (≥ 24 and ≤ 33 mm Hg at 8 AM and ≥ 21 and ≤ 33 mm Hg at 10 AM on Screening Two visit and Baseline visit in one or both eyes off treatment \[after a washout phase in those subjects who were receiving ocular hypotensive therapy\]). Exclusion Criteria: Ophthalmic exclusion criteria: * Uncontrolled intraocular hypertension defined as \> 33 mm Hg in either eye at either of the screening/baseline visits (after a washout phase in those subjects who were currently receiving ocular hypotensive therapy). * Receiving more than one medication for IOP in either eye at time of screening. * Abnormal central corneal thickness. * BCVA worse than 20/200 (logMAR 1.0) in either eye * Significant visual field loss. * Acute angle-closure glaucoma or appositional or very narrow anterior chamber angle in either eye.