Fluctuations of female sex hormones during the menstrual cycle influence pain perception. Endogenous pain is pronounced in the follicular phase of the menstrual cycle. The investigators tested the primary hypothesis that the women having surgery during their follicular phase have more acute pain and require more opioids than those in the luteal phase, and secondarily the investigators tested that women who have surgery during their follicular phase have more incisional pain at 3 month postoperatively.
127 adult females having laparoscopic cholecystectomy were randomized to have surgery during the luteal or follicular phase of their menstrual cycle. Standardized anesthesia and pain management regimen was given to all patients. Pain and analgesic consumption were evaluated in PACU and every four hours in first 24 hours. Adverse effects were also questioned every four hours. Time to oral intake and ambulation were recorded. Post-surgical pain, hospital anxiety and depression scale, and SF-12 questionnaire were also evaluated at 1- and 3-month visits.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
64
The anxiety/depression scale (HAD) was used to assess anxiety and depression.
The SF 12 test (SHORT FORM 12) was used to evaluate quality of life.
Visual analogue score vas used to evaluate pain.
Adnan Menderes University Medical Faculty, Anesthesiology and Reanimation Department
Aydin, Turkey (Türkiye)
Persistent surgical pain after laparoscopic cholecystectomy assessed by VAS scale
Time frame: 3 months
The anxiety and depression was evaluated with Hospital anxiety and depression scale.
Time frame: 3 months
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