Investigate clinical effects (reduction of number of syncope and associate symptoms) of suspension of vasoactive drugs in patients affected by vasodepressor reflex syncope.
Several drugs which are commonly used in clinical practice, such as antihypertensive, antiarrhythmic and psychiatric drugs, are associated with orthostatic hypotension and syncope. This phenomenon is much more evident in the elderly and with multiple therapies. The present study was aimed to investigate, in patients affected by reflex syncope, the clinical effects (reduction in syncope recurrence and associated symptoms) and the laboratory tests (negativization of carotid sinus massage and tilt table test) when such drugs are discontinued or reduced
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
58
Continue current vasoactive therapy
Discontinuation of any vasoactive therapy or reduction of vasoactive drug therapies as much as possible according to clinical judgment.
Dipartimento di Cardiologia, Ospedali del Tigullio
Lavagna, Italy
Recurrence of syncope or presyncope and adverse events
Combined end-point of rate of patients with recurrence of (pre)syncope and adverse events
Time frame: From date of randomization until the date of first documented syncope or adverse event, whichever came first, assessed up to 2 years
Syncope
Recurrence of syncope
Time frame: From date of randomization until the date of first documented syncope or adverse event, whichever come first, assessed up to 2 years
Presyncope
Burden of presyncope, measured as number of episodes of presyncope/s per month assessed up to 2 years by mean of a patient's diary
Time frame: From date of randomization until the date of first documented syncope or adverse event, whichever came first, assessed up to 2 years
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