This study will investigate the effect of Spanish Black Radish on phase I and phase II enzyme activity in healthy adult males. The primary objective is to determine the effect on phase I and phase II enzyme activity by measuring plasma and urine acetaminophen metabolite concentrations prior to and after a 28 day supplementation period with Spanish black radish product.
Study Type
INTERVENTIONAL
Allocation
NA
Masking
NONE
Enrollment
20
KGK Synergize Inc.
London, Ontario, Canada
Effect on Phase I and II enzymes
The effect on phase I and phase II enzyme activity determined by measuring plasma and urine acetaminophen metabolite concentrations Subjects will ingest 1000 mg of acetaminophen. Blood will be collected at 0, 2, 4, 6 and 8 hours after acetaminophen dosage for the analysis of plasma acetaminophen metabolites. These measurements will be performed prior to and after 4 weeks of treatment with Spanish Black Radish product.
Time frame: 4 weeks
Assessment of Hormone Levels
Assessment of serum total testosterone, free testosterone and estradiol 17 beta
Time frame: 4 weeks
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