To investigate long-term effects on cardiovascular mortality/morbidity and renal failure in type 1 diabetes patients former randomized to intensive insulin treatment
The Stockholm Diabetes Intervention Study (SDIS) aimed to determine whether intensified insulin treatment were feasible and led to less serious diabetic complications. 102 patients with type 1 diabetes mellitus were randomized (October 1982 to March 1984) to intensified conventional treatment (ICT; n=48) or standard treatment (ST; n=54). The randomized SDIS study lasted for 7.5 years, whereas 96 patients were fully evaluated. Thereafter patients were assigned to their regular clinical visits. In the present interventional study we wanted to study all-cause mortality and cardiovascular outcomes (i.e. myocardial infarction and stroke), and renal failure in the SDIS cohort until december 31 2011.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
102
Mealtime insulin (Actrapid) Basal insulin (Monotard)
Insulin Mixtard
Södersjukhuset
Stockholm, Sweden
Cardiovascular Mortality
All cause mortality and composite mortality from myocardial infarction, stroke and renal failure
Time frame: Up to 28 years
Morbidity of Cardiovascular Complications
Morbidity of: coronary heart disease, stroke and renal failure
Time frame: Up to 28 years
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