Collection of Plasma Samples for Squamous Cell Carcinoma of the Head and Neck Patients

Cliniques universitaires Saint-Luc- Université Catholique de Louvain400 enrolled

Overview

The investigators will collect plasma samples at baseline, during treatment, and at progression.

In this study, the investigators will collect plasma samples at baseline, during treatment, and at progression. This plasma bank will be used to study the potential value of some biomarkers to predict treatment activity or resistance to cetuximab or other targeted agents

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Squamous Cell Carcinoma of the Head and Neck

Interventions

Plasma samplesOTHER

Plasma samples at baseline (and one whole blood sample) and at every radiological evaluations

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients treated with radiation therapy and cetuximab according to Bonner et al * patients treated with cetuximab in combination with chemotherapy according to Vermorken et al. * patients treated with a molecular targeted agent as a part of a clinical study Exclusion Criteria: * patients with another type of head and neck cancer * patients non treated with targeted therapies

Locations (5)

Clinique Saint-Pierre

Ottignies, Brabant Wallon, Belgium

RECRUITING

Grand Hôpital de Charleroi

Charleroi, Hainaut, Belgium

RECRUITING

Centre Hospitalier Jolimont-Lobbes-Nivelles-Tubize

Haine-Saint-Paul, Belgium

Outcomes

Primary Outcomes

Prospective storage of plasma samples of patients treated with cetuximab or other targeted agents

All the analyses will be done when we have enough of collected samples

Time frame: one year after the collection

Central Contacts

Jean-Pascal Machiels, MD, PhD

CONTACT

0032 2 764 jean-pascal.machiels@uclouvain.be

Séverine Carlier, MD

CONTACT

0032 2 764 severine.carlier@uclouvain.be

Data from ClinicalTrials.gov

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