Dose-Escalation of Botulinum Toxin in Subjects With Osteoarthritis of the Knee

Inclusion Criteria: * Osteoarthritis of the knee * Fully weight bearing in the index knee with or without the need for assistive/orthopaedic devices * Pain score ≥40 mm of the index knee * Committing to continue using their assistive/orthopaedic device throughout the study using the same regimen Exclusion Criteria: * Any infection in the index knee or inflammatory skin disease or other inflammatory diseases at the index knee or the anticipated injection site * Surgery on the symptomatic knee within the previous 12 months or arthroscopy in the index knee in the past 3 months * Any painful orthopaedic disorder of the back or hip which is likely to interfere with the safety or efficacy assessments * A joint disorder other than osteoarthritis in the index knee which could potentially interfere with the safety or efficacy assessments