Hemodynamic Repercussions of Noninvasive Ventilation

Federal University of Uberlandia30 enrolled

Overview

The noninvasive ventilation (NIV) is a method of ventilatory support that does not require artificial airway. Its application is associated with complex hemodynamic repercussions, therefore is important to identify them for safety and effectiveness of the technique application. The main objective of this research is to evaluate the hemodynamic repercussions using doppler echocardiography in healthy volunteers submitted a different values of positive end expiratory pressure (PEEP) by the following ventilatory modes: Continuous positive airway pressure (CPAP) and Bilevel. The study hypothesis is that the positive end expiratory pressure (PEEP) may cause hemodynamic repercussions as: reduction of the ventricles pre-load, left ventricle after load, cardiac output and reduction in the diameter of the superior vena cava, due to the increase in the intrathoracic pressure and pulmonary volumes.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Haemodynamic Rebound

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy individuals * Age between 18 and 40 years old * Non smoker Exclusion Criteria: * Clinical signs or symptoms of any disease decompensation * History of blood pressure variations by autonomic dysfunction * Sense of claustrophobia * Smoker

Outcomes

Primary Outcomes

Hemodynamic repercussions of different levels of positive end expiratory pressure applied noninvasively, measured by echocardiography

The hemodynamic variables evaluated are: ventricular preload, left ventricle afterload, cardiac output, blood pressure and the vena cava's diameter. All variables will be assessed by echocardiography

Time frame: 5 minutes

Secondary Outcomes

Measurement of cardiac output as a predictor of cardiopulmonary adaptation to different pressures.