A Study to Evaluate the Safety of ASP2408 After Subcutaneous Administration to Healthy Male Subjects

Inclusion Criteria: * BMI (at screening): ≥ 17.6 kg/m2, \< 26.4 kg/m2 * Healthy, as judged by the investigator or subinvestigator based on the results of medical examination (subjective symptoms and objective findings) and all tests obtained at screening and during the period from hospitalization (Day -2) to immediately before study drug administration * Subjects who agree to use effective contraception until 90 days after study drug administration Exclusion Criteria: * Received any investigational drugs in other clinical or post-marketing studies within 120 days before the study or is scheduled to receive any investigational drugs * Donated 400 mL of whole blood within 90 days before the study or during the period from the screening, 200 mL of whole blood within 30 days, or blood components within 14 days before the study, or is scheduled to donate 400 mL of whole blood or blood components * Received medication within 7 days before hospitalization (Day -2) or is scheduled to receive medication * Received systemic medications influencing immune functions (e.g., steroids, tacrolimus hydrate, anticancer drugs, and biological products) within 365 days before study drug administration * Received a live virus vaccine (e.g., BCG, polio, measles, and rubella) within 180 days before study drug administration, or cannot agree not to receive these vaccines for 180 days after study drug administration * Received a live virus vaccine (e.g., BCG, polio, measles, and rubella) within 180 days before study drug administration, or cannot agree not to receive these vaccines for 180 days after study drug administration * A deviation from the normal range of blood pressure, pulse rate, body temperature, or standard 12-lead ECG (see Table 3.3-1) at screening or the day before study drug administration (Day -1) * Any deviation of the normal ranges in laboratory tests before study drug administration * Failure to meet any criteria for standard 12-lead ECG for QT assessment at screening * A positive result for tuberculosis test * Concurrent or history of drug allergies, anaphylaxis, or severe allergic reaction * Upper GI disease * Concurrent or previous hepatic disease (e.g., viral hepatitis and drug-induced liver injury) * Concurrent or previous heart disease (e.g., congestive heart failure, angina pectoris, and arrhythmia requiring treatment) * Concurrent or previous respiratory disease (e.g., bronchial asthma and chronic bronchitis; except for a history of childhood asthma) * Previous operation of gut excision * Concurrent or previous renal disease (e.g., acute renal failure, glomerulonephritis, and interstitial nephritis; except for a history of calculus) * Concurrent or previous endocrine disease (e.g., hyperthyroid, abnormality of growth hormone) * Concurrent or previous cerebrovascular disorder (e.g., cerebral infarction) * Concurrent or previous malignant tumor * Concurrent or previous serious infection (e.g., sepsis, pneumonia requiring hospitalization, and pyelonephritis)