Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women

Mansoura University500 enrolled

Overview

Laparoscopic Ovarian Drilling is a valid procedure for infertile anovulatory women with polycystic ovarian syndrome who failed to get pregnant or to ovulate with ovulation induction medications as clomiphene citrate or exogenous gonadotropins. The reasearchers supposed that endometrial curettage at time of laparoscopic ovarian drilling may boost fertility in these women.

Current literature suggests that endometrial biopsy may improve pregnancy rates in infertile women hence the investigators will examine whether this hypothesis will apply to infertile PCOS women undergoing laparoscopic ovarian drilling to overcome ovulatory disfunction or not.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

500

Conditions

Infertility Polycystic Ovarian Syndrome

Interventions

Endometrial CurrettagePROCEDURE

Only Laparoscopic ovarian drilling without endometrial currettage will be performed

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 39 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. subfertile women with anovulatory infertility due to polycystic ovarian syndrome (PCOS). 2. Women who failed to get pregnant after at least 6 months of ovulation induction cycles with clomiphene citrate or exogenous gonadotropins 3. Patent Fallopian tubes as confirmed by hysterosalpingography 4. Fertile semen parameters of the partneraccording to criteria of World Health Organization (WHO 2010). Exclusion Criteria: 1. women with BMI \>30, 2. age \< 18 years or \> 39 years, 3. women with ovarian cysts identified by transvaginal ultrasound 4. male factor infertility 5. Tubal factor infertility as suggested by hystrosalpingogram (HSG) 6. Women with congenital malformations in the uterus as bicornuate or septate uterus as suggested by HSG.

Locations (1)

Mansoura University Teaching Hospital

Al Mansurah, Egypt

RECRUITING

Outcomes

Primary Outcomes

live birth rate per woman randomized

Time frame: 15 months

Secondary Outcomes

pregnancy rate per woman randomised

Time frame: 6 months

Central Contacts

Ahmed Gibreel, MD

CONTACT

00201004045733 ahmedfathgi@yahoo.com

Data from ClinicalTrials.gov

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