To assess the effect of prophylactic antiglaucoma agents in prevention of acute intraocular pressure rise after intravitreal injection.
Acute intraocular pressure elevation after intravitreal injection of bevacizumab was proven.Acute intraocular pressure elevation most probably is volume related and long term intraocular pressure elevation relates to pharmacologic features of the medications which results in anatomic changes in the angle of anterior chamber.Numerous studies found an intraocular pressure elevation right after the injection and quick normalization within maximally 30 minutes.This intraocular pressure elevation which lasts about 30 minutes, can result in irreversible visual loss especially in patients with critical remaining nerve fibers in the optic nerve head, as occurs in glaucomatous patients. Is there any way to prevent or even shorten this time of intraocular pressure elevation? We tried in our study to find a suitable response for a question above, so we used several anti-glaucoma agents (Timolol, Brimonidine, Acetazolamide, Mannitol versus placebo) as a prophylaxis to prevent acute intraocular pressure elevation right after intravitreal bevacizumab injection.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
70
2 drops of timolol, 10 minutes apart, 1-2 hours before intravitreal injection
Brimonidine eyedrop, 2 drops 5 minutes apart, 1-2 hours before intravitreal injection
Acetazolamide tablet, 2 tabs, 2 hours before intravitreal injection
Retina Research Center, Khatam eye Hospital
Mashhad, Razavi Khorasan Province, Iran
change in IOP
the change in intraocular pressure after intravitreal injection of bevacizumab
Time frame: 0, 5, 10, 15, 30 minutes after injection
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Intravenous mannitol, 1.5 gram/kg, 1 hour before intravitreal injection
Artificial tears, 2 drops, 1-2 hours before intravitreal injection