A Long-Term Safety Study of ALKS 5461

Inclusion Criteria: * Agree to use an approved method of contraception for the duration of the study * Have the potential to safely benefit from the administration of ALKS 5461 * Have a diagnosis of major depressive disorder (MDD) * Additional criteria may apply Exclusion Criteria: * Have a positive test for drugs of abuse * Currently pregnant or breastfeeding * Have a current primary Axis-I disorder other than MDD * Have used opioid agonists (eg, codeine, oxycodone, tramadol, morphine) or opioid antagonists (eg, naloxone, naltrexone) within 14 days * Have received electroconvulsive therapy treatment within the last 2 years, or received more than 1 course of electroconvulsive treatment during their lifetime * Have attempted suicide within the past 2 years * Have a history of intolerance, allergy, or hypersensitivity to buprenorphine or opioid antagonists (eg, naltrexone, naloxone) * Have had a significant blood loss or blood donation within the past 60 days * Additional criteria may apply