To evaluate the effect of pre-injection of lidocaine on myoclonus induced by induction with etomidate during general anesthesia in elderly patients
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
272
Lidocaine injection should be give before the injection of etomidate. In groups L1 and L2, 20 mg and 30 mg lidocaine injection will be diluted to 2ml separately.
1 minute after the injection of lidocaine, 0.3 mg/kg etomidate will be given in 30 to 60 s.
2 ml normal saline will be given 1 minute before the injection of etomidate in patients in group C, and in group L1 and L2, normal saline is used to dilute lidocaine injection to 2 ml.
TangDu Hospital,FMMU
Xi’an, Shanxi, China
RECRUITINGseverity of myoclonus induced by
myoclonic movements are graded as 0=no myoclonus, 1=mild myoclonus (short movement of a body segment e.g., a finger or a wrist), 2=moderate myoclonus (mild movement of two different muscle groups e.g., face and arm), or 3=severe myoclonus (intense myoclonic movement in two or more muscle groups, fast adduction of a limb)
Time frame: 90 seconds from the beginning of etomidate injection
intensity of injection pain
The intensity of pain was graded using a verbal rating scale. 0-None (negative response to questioning) 1. Mild pain (pain reported only in response to questioning without any behavioral signs) 2. Moderate pain (pain reported in response to questioning and accompanied by a behavioral sign or pain reported spontaneously without questioning) 3. Severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawl or tears)
Time frame: during the injection of etomidate, expected to be within 1 minutes
hemodynamic parameters after injection of etomidate
Heart rate and mean arterial pressure will be recorded before induction, before the injection of etomidate, 1 minute and 2 minutes after injection of etomidate
Time frame: baseline to 2 minutes after injetion of etomidate
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
0.02 mg/kg midazolam will be given to the patients in all groups 90 s after the injection of etomidate.
3 μg/kg fentanyl will be given to patients in all groups after the injection of midazolam.
0.6 mg/kg rocuronium will be given to patients in all groups after the injection of fentanyl.