The aim of this study is to improve the usability of biomarkers for the timely prediction of new complications following a cerebral hemorrhage, especially in combination with invasive, functional and local measurements for patients with aneurysmal subarachnoid hemorrhage (SAH). Based on analyzed biomarker profiles the chosen therapy efforts are assessed in their immediate and longer-term effectiveness.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
310
Daily (21 days) analysis of biomarker in serum, in liquor and in micro-dialysate
Single analysis of biomarker in serum and liquor
Department of Neurosurgery, University Hospital RWTH Aachen
Aachen, North Rhine-Westphalia, Germany
RECRUITINGBiomarker in serum, cerebrospinal fluid and parenchyma after aneurysmal SAH
Temporal development of alternative biomarkers in serum, cerebrospinal fluid and parenchyma after aneurysmal SAH, and their response as influenced by the treatment path.
Time frame: Each participant will be followed at hospital stay for an expected average of 3 weeks. The outcome measure will be assessed after 24 month.
Clinical outcome
Clinical outcome of patients depending on treatment algorithm and observed development of alternative biomarkers
Time frame: Each participant will be followed at hospital stay for an expected average of 3 weeks. The outcome measure will be assessed after 24 month
Image morphological outcome
Image morphological outcome of patients depending on treatment algorithm and observed development of alternative biomarkers
Time frame: Each participant will be followed at hospital stay for an expected average of 3 weeks. The outcome measure will be assessed after 24 month
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