Prevention of Myocardial Dysfunction and Injury Resulting From Salter Innominate Osteotomy by Caudal Block

Si-Qin Chen40 enrolled

Overview

The goal of the present study was to investigate the role of pro-inflammatory cytokines in myocardial dysfunction and injury resulting from noncardiac injury in children and whether or not anti-inflammatory treatment with caudal block prevents pro-inflammatory cytokines-associated myocardial dysfunction and injury following noncardiac surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Cardiac Dysfunction Myocardial Injury

Interventions

ropivacaineDRUG

caudal block with 1 ml/kg of ropivacaine 0.2%

salineDRUG

caudal block with 1 ml/kg of saline

Eligibility

Sex: ALLMin age: 1 YearMax age: 5 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children diagnosed for developmental dysplasia of the hip (DDH) undergoing Salter innominate osteotomy will be recruited into the study. Exclusion Criteria: * Children with anemia, electrolyte disturbances, abnormal acid-base status, bleeding diathesis, history of allergy to local anesthetics, neurologic and spinal diseases, skin infections on the caudal area, renal dysfunction, symptomatic cardiovascular and respiratory disease

Locations (1)

Xinhua Hospital

Shanghai, China

RECRUITING

Outcomes

Primary Outcomes

change from baseline(before induction of anesthesia) in plasma concentrations of NT(N terminal)-proBNP at arrival in the postanesthesia care unit

Time frame: baseline(before induction of anesthesia), arrival in the postanesthesia care unit

change from baseline(before induction of anesthesia) in plasma concentrations of NT(N terminal)-proBNP at 3h after surgery

Time frame: baseline(before induction of anesthesia), 3h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of NT(N terminal)-proBNP at 24h after surgery

Time frame: baseline(before induction of anesthesia), 24h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of NT(N terminal)-proBNP at 48h after surgery

Time frame: baseline(before induction of anesthesia), 48h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of NT(N terminal)-proBNP at 72h after surgery

Time frame: baseline(before induction of anesthesia), 72h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of CK(creatine kinase)-MB at arrival in the postanesthesia care unit

Time frame: baseline(before induction of anesthesia), arrival in the postanesthesia care unit

change from baseline(before induction of anesthesia) in plasma concentrations of CK(creatine kinase)-MB at 3h after surgery

Time frame: baseline(before induction of anesthesia), 3h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of CK(creatine kinase)-MB at 24h after surgery

Time frame: baseline(before induction of anesthesia), 24h after surgery

Central Contacts

SiQin Chen, MD

CONTACT

+8613918085974 chensiqin1983@hotmail.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

change from baseline(before induction of anesthesia) in plasma concentrations of CK(creatine kinase)-MB at 48h after surgery

Time frame: baseline(before induction of anesthesia), 48h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of CK(creatine kinase)-MB at 72h after surgery

Time frame: baseline(before induction of anesthesia), 72h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of cTn(troponin)I at arrival in the postanesthesia care unit

Time frame: baseline(before induction of anesthesia), arrival in the postanesthesia care unit

change from baseline(before induction of anesthesia) in plasma concentrations of cTn(troponin)I at 3h after surgery

Time frame: baseline(before induction of anesthesia), 3h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of cTn(troponin)I at 24h after surgery

Time frame: baseline(before induction of anesthesia), 24h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of cTn(troponin)I at 48h after surgery

Time frame: baseline(before induction of anesthesia), 48h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of cTn(troponin)I at 72h after surgery

Time frame: baseline(before induction of anesthesia), 72h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of TNF(tumor necrosis factor)-α at arrival in the postanesthesia care unit

Time frame: baseline(before induction of anesthesia), arrival in the postanesthesia care unit

change from baseline(before induction of anesthesia) in plasma concentrations of TNF(tumor necrosis factor)-α at 3h after surgery

Time frame: baseline(before induction of anesthesia), 3h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of TNF(tumor necrosis factor)-α at 24h after surgery

Time frame: baseline(before induction of anesthesia), 24h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of TNF(tumor necrosis factor)-α at 48h after surgery

Time frame: baseline(before induction of anesthesia), 48h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of TNF(tumor necrosis factor)-α at 72h after surgery

Time frame: baseline(before induction of anesthesia), 72h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of IL(interleukin)-6 at arrival in the postanesthesia care unit

Time frame: baseline(before induction of anesthesia), arrival in the postanesthesia care unit

change from baseline(before induction of anesthesia) in plasma concentrations of IL(interleukin)-6 at 3h after surgery

Time frame: baseline(before induction of anesthesia), 3h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of IL(interleukin)-6 at 24h after surgery

Time frame: baseline(before induction of anesthesia), 24h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of IL(interleukin)-6 at 48h after surgery

Time frame: baseline(before induction of anesthesia), 48h after surgery

change from baseline(before induction of anesthesia) in plasma concentrations of IL(interleukin)-6 at 72h after surgery

Time frame: baseline(before induction of anesthesia), 72h after surgery

Secondary Outcomes

change from baseline(just before the start of surgery) in MAP(mean arterial pressure) at arrival in the postanesthesia care unit

Time frame: baseline(just before the start of surgery), at arrival in the postanesthesia care unit

change from baseline(just before the start of surgery) in MAP(mean arterial pressure) at 3h after surgery

Time frame: baseline(just before the start of surgery), 3h after surgery

change from baseline(just before the start of surgery) in CVP(central venous pressure) at arrival in the postanesthesia care unit

Time frame: baseline(just before the start of surgery), at arrival in the postanesthesia care unit

change from baseline(just before the start of surgery) in CVP(central venous pressure) at 3h after surgery

Time frame: baseline(just before the start of surgery), 3h after surgery

change from baseline(just before the start of surgery) in HR(heart rate) at arrival in the postanesthesia care unit

Time frame: baseline(just before the start of surgery), at arrival in the postanesthesia care unit

change from baseline(just before the start of surgery) in HR(heart rate) at 3h after surgery

Time frame: baseline(just before the start of surgery), 3h after surgery