Investigation of the Effect of E.-Coli-Nissle as Supporting Therapy to Standard Care of Diabetes Mellitus Type II

Inclusion Criteria: * diabetes mellitus type 2; * HbA1c \>7 % (stable für 6 months, max. variation of 0,5%) * stable oral antidiabetic therapy for 6 months with Metformin, Vildagliptin, Gliniden or without oral Antidiabetics * age of 45 to \<80 years (men and women) Exclusion Criteria: * Myocardial infarction or stroke within the last 5 years * Therapy with acarbose * Acute peripheral arterial disease within the last 12 months * Instable metabolic situation * Uncontrolled hypertension * Body-Mass-Index ≥ 35 kg/m² * Smokers * Daily consumption of probiotic food * Malignant disease within the last 5 years * Status post transplantation * Immunosuppressive therapy within the last 3 months * Therapy with antibiotics * Macroalbuminuria * Severe liver disease