PXVX0200 (CVD103-HgR) vs Shanchol in Mali

Inclusion Criteria: * Able to understand the study and give consent (either written or through a process that involves audio tapes explaining all aspects of the study and the consent form in local languages \[Bambara and French\] followed by making a mark and signature by a literate witness) * Healthy men or women, age 18 to 45 years (inclusive) without significant medical history * Women of child-bearing potential must have negative urine pregnancy test at baseline, prior to vaccination. They must also be willing to use adequate birth control for the duration of the 28-day study and have additional pregnancy tests if indicated. Effective methods of birth control for this study include abstinence, intrauterine device (IUD), oral or depot contraceptive, or barrier plus spermicide * Willingness to remain in the study area until at least 42 days after receipt of the first vaccine dose Exclusion Criteria: * Health care workers who have direct contact with patients who are immune deficient, HIV-positive, or have an unstable medical condition * Clinically significant history of immunodeficiency, cardiovascular disease, respiratory disease, endocrine disorder, liver disease, renal disease, gastrointestinal disease, neurologic illness, psychiatric disorder requiring hospitalization, current drug or alcohol abuse * History of an abnormal stool pattern or regular use of laxatives * Previously received a licensed or investigational cholera vaccine * History of cholera illness