Impact of Exercise on Cognitive Impairment in End-Stage Renal Disease

University of Kansas Medical Center20 enrolled

Overview

The purpose of this study is to evaluate the impact of 12 weeks of exercise on cognition in patients with end stage renal disease.

Patients with end stage renal disease have higher cognitive impairment than general population. They also have decreased physical and functional capacity. Exercise has shown to improve cognition in general population. This study will evaluate if exercise improves cognition in dialysis patients. It will also evaluate whether exercise affects performance in daily activities, mood or depression and inflammatory markers in the blood.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Cognitive Impairment End-Stage Renal Disease

Interventions

Aerobic ExerciseOTHER

Each exercise session will be conducted at the KUMC Exercise and Cardiovascular Health (REACH) Laboratory. Exercise sessions will include a warm-up period, exercise period and a cool down period. Exercise intervention individualized based on health of participant. Subject will be asked to completed two exercise sessions per week for 12 weeks.

Standard Care DialysisPROCEDURE

12 weeks of standard of care.

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with ESRD on dialysis * Age greater than 20 years * Have means of transportation to and from the exercise session * Speak English (as the neuropsychological tests will be performed in English) Exclusion Criteria: * Recent myocardial infarction (within 6 weeks), unstable angina, uncontrolled arrhythmias, congestive heart failure (\> NYHA grade II) * History of stroke in the last 2 months * Active respiratory disease * Uncontrolled hypertension * Severe uncontrolled diabetes * Persistent predialysis hyperkalemia * Active decompensated liver disease * Symptomatic peripheral vascular disease * Musculoskeletal abnormalities that will be prohibit their participation in the exercise program * Health conditions needing frequent hospitalizations * Other health conditions causing inability to follow exercise program correctly * Unwillingness to participate in structured exercise program * Current use of antipsychotics or anti-epileptics * Inability to hear, read or write which will limit their ability to perform the cognitive tests

Locations (1)

University of Kansas Medical Center

Kansas City, Kansas, United States

Outcomes

Primary Outcomes

Feasibility

Subject compliance with exercise training

Time frame: Up to 26 Weeks

Secondary Outcomes

Cognitive function

Measured using a standard battery of neuropsychological tests.

Time frame: Baseline, within1 week before and within 1 week after exercise intervention

Markers of inflammation

Markers of inflammation will be evaluated before and after exercise intervention

Time frame: Baseline, within 1 week before and within 1 week after exercise intervention

Data from ClinicalTrials.gov

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