Ultrathin Bronchoscope and Radial Endobronchial Ultrasound (R-EBUS) With Fluoroscopy Versus Standard Fiberoptic Bronchoscopy (FB) (P00029233 )

Inclusion Criteria: 1. Patients with a solid lung lesion 2-5cm identified on chest CT with the intention to undergo bronchoscopic evaluation. If the lesion is partially solid (ie there is a ground glass component) then the solid portion must make up \>75% of the lesion and measure at 2-5cm.The decision to pursue biopsy will be made by the treating physician and agreed upon by the patient. This will include patients determined to have an intermediate risk of malignancy (5-65%) and those non-surgical candidate with higher risk lesions in need of diagnosis for alternative treatment. OR 2. Patients with a solid lung lesion 2-5cm identified on chest CT that are surgical candidates with a high probability of cancer (\>65%) will be referred for surgical evaluation. If the lesion is partially solid (ie there is a ground glass component) then the solid portion must make up \>75% of the lesion and measure at 2-5cm. If the patient refuses surgery or if the surgeon requests a definitive diagnosis prior to surgery the patient will have the option to be included in this study. All sites will use the same online calculator to document probability of malignancy. 3. Are at least 22 years old, 4. Lack Bleeding disorders, and 5. Are able to provide informed consent Exclusion Criteria: 1. Patients with a pure ground-glass opacity identified on chest CT 2. Patients with endobronchial involvement seen on chest CT. 3. Patients who refuse to participate, 4. Are less than 22 years of age, 5. Lack fitness to undergo flexible bronchoscopy as determined by the bronchoscopist prior to procedure, and 6. Are unable to provide informed consent 7. Pregnant