The aim of this study is to examine the therapeutic effect of green tea extract on obese women and the correlation analysis between traditional Chinese medicine syndrome and obese related hormone peptides.
Obesity has become a noticeable and worldwide public health problem recently. According to the WHO survey in 2005, 1.6 billion and 400 million adults were found overweight and obese, respectively. In Taiwan, there are more than 30% found overweight in the national survey in 2009. Compare with the ones done in 1999 and 2005, a rising trend of the prevalence of obesity is found. Furthermore, the incidence and prevalence of obesity are also increasing worldwide, especially in the developing and newly industrialized nations. In addition, obesity is related to some chronic diseases, like diabetes mellitus, hyperlipidemia and cardiovascular diseases, which are major lethal health concerns in Taiwan and many developing countries. Taken together, obesity emerges as an important issue lately. The aim of the study is to evaluate the therapeutic effect and safety of green tea extract on demographic characteristics and obesity-related hormone peptide of obese women and to establish an obesity Traditional Chinese Medicine (TCM) syndromes questionnaire, which will undergo well assessing of reliability and validity. Second, we intent to utilize the TCM syndromes and Quality of Life (SF-12, WHO) questionnaire to 200 obesity women for the correlation analysis of TCM syndromes, obesity related hormone peptides and quality of life. The results of this study are expected to assess the effect and safety of green tea extract on obese women and improve the scientific diagnosis of TCM with a quantitative measurement by this questionnaire.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
92
500mg, three times a day, duration:12 weeks
Taipei City Hospital
Taipei, Taiwan, Taiwan
composite of anthropometric measures
composite include body weight, waist circumference, hip circumference
Time frame: compare between the beginning of the study and after 12 weeks of treatment.
Hormone peptide change
hormone peptides such as leptin、adiponectin、ghrelin、fasting insulin resistance、APOB、APOA1
Time frame: compared between the beginning of the study and after 12 weeks of treatment
biochemical characteristic change
blood sugar, creatinine, aminotransferases aspartate, aminotransferases alanine, uric acid and
Time frame: compare between the beginning of the study and after 12 weeks of treatment.
traditional chinese medicine syndrome classification
Use questionaire to classify traditional chinese medicine syndrome in obese women
Time frame: compare between the beginning of the study and after 12 weeks of treatment.
Quality of life evaluation
(1)12-item Short-Form Health Survey (2)WHOQoL-BREF
Time frame: compare between the beginning of the study and after 12 weeks of treatment.
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