Radial Artery Function Following Trans-radial Cardiac Catheterisation

University of Edinburgh5 enrolled

Overview

The investigators will study Radial artery injury and endothelial function following trans-radial cardiac catheterisation. Radial artery injury will be quantified pre- and post- angiography using Optical Coherence Tomography. The participants will also have radial endothelial function assessed using flow-mediated dilatation at baseline, 24 hours, one week, one month and three months post- angiography. Blood will be taken pre and 24 hours post angiography for characterisation of endothelial progenitor cell numbers and function. The hypothesis is that trans-radial catheterisation will cause a reduction in flow-mediated dilatation which peaks at 24 hours and recovers at three months. The investigators hope to correlate the rate of this recovery with peri-procedural progenitor cell numbers.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Atherosclerosis

Interventions

Coronary angiographyPROCEDURE

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Stable outpatient population aged between 18-85 attending for trans-radial cardiac catheterisation Exclusion Criteria: * Recent myocardial infarction (\<3 months) * Severe aortic stenosis * Chronic renal failure (eGFR\<30) * Inability to give informed consent

Outcomes

Primary Outcomes

Change in Flow-mediated dilatation

Radial artery flow-mediated dilatation will be assessed at the above stated time points

Time frame: baseline, 24 hours, one week, four weeks and three months post-angiography

Secondary Outcomes

Radial artery injury

Optical coherence tomography examination of the radial artery will be made at baseline and following sheath insertion.

Time frame: Baseline and up to 1 hour Post angiograpy sheath insertion

Endothelial progenitor cell number an function Endothelial progenitor cell number and function

Time frame: Baseline and at 24 hours post-angiogram