Epidemiological studies suggest that certain foods rich in flavanols, including cocoa products, red wine, and tea, are associated with decreased cardiovascular mortality and morbidity. Dietary interventional studies have corroborated this finding and showed that flavanols can acutely and after sustained ingestion improve surrogate markers of cardiovascular risk including endothelial function. Endothelial dysfunction is the key event in the development and progression of cardiovascular disease. The aim of the study is to assess sex specific effects of cocoa flavanols on endothelial and vascular function in healthy subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
24
Flavanol intervention products (250 mg, 500 mg and 750 mg flavanols)
Calorically, micro- and macronutrient matched control product free of flavanols
Division of Cardiology, Pulmonology and Vascular Medicine
Düsseldorf, Germany
Absolute change of Flow-mediated Vasodilation (FMD)
Time frame: 2 hours
Pulse wave velocity
Measured by SphygmoCor
Time frame: 2 hours
Augmentation index
Measured by SphygmoCor
Time frame: 2 hours
Ambulatory blood pressure
automatical measurements
Time frame: 2 hours
Plasma flavanol metabolites
Measured by HPLC
Time frame: 2 hours
laboratory safety parameters
blood/urine samples for safety assessment (haematology, biochemistry, and urinalysis)
Time frame: 2 hours
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