The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with chronic atrophic dermatitis to gain better insight into pathogenesis of chronic infection with Borrelia burgdorferi sensu lato.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
50
UMC Ljubljana, Department of Infectious Diseases
Ljubljana, Slovenia
RECRUITINGinflammatory proteins in patients with chronic atrophic dermatitis
The inflammatory immune profiles will be assessed using Luminex to measure the expression of cytokines and chemokines representative of innate and adaptive TH1, TH2, TH17, and B cell responses.
Time frame: up to 24 months
clinical characteristics of patients with chronic atrophic dermatitis treated with doxycycline for 14 or 28 days
Time frame: at enrollment, at 2, 6 12 and 24 months follow-up
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