To compare the effect of propofol and etomidate in hysteroscopy on postoperative sedation and cognitive function in elderly patients
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
120
During anesthesia maintenance, all patients will be given remifentanil at the speed of 0.2\~0.4 μg/kg/min.
Heart rate
heart rate will be recorded immediately after the entrance to the operating room, at the beginning of induction, 2.5 min, 5 min, 7.5 min, 10 min, 15 min, 20 min, 25 min and 30 min after the beginning of induction, 5 min, 10 min, 15 min, 20 min, 30 min, 45 min and 60 min after the operation.
Time frame: Immediately after the entrance to the operating room until until 60 minutes after the operation
Mean arterial pressure
Mean arterial pressure will be recorded immediately after the entrance to the operating room, at the beginning of induction, 2.5 min, 5 min, 7.5 min, 10 min, 15 min, 20 min, 25 min and 30 min after the beginning of induction, 5 min, 10 min, 15 min, 20 min, 30 min, 45 min and 60 min after the operation.
Time frame: Immediately after the entrance to the operating room until until 60 minutes after the operation
Pulse oxygen saturation
Pulse oxygen saturation will be recorded immediately after the entrance to the operating room, at the beginning of induction, 2.5 min, 5 min, 7.5 min, 10 min, 15 min, 20 min, 25 min and 30 min after the beginning of induction, 5 min, 10 min, 15 min, 20 min, 30 min, 45 min and 60 min after the operation.
Time frame: Immediately after the entrance to the operating room until until 60 minutes after the operation
Respiratory rate
Respiratory rate will be recorded immediately after the entrance to the operating room, at the beginning of induction, 2.5 min, 5 min, 7.5 min, 10 min, 15 min, 20 min, 25 min and 30 min after the beginning of induction, 5 min, 10 min, 15 min, 20 min, 30 min, 45 min and 60 min after the operation.
Time frame: Immediately after the entrance to the operating room until until 60 minutes after the operation
Narcotrend index
Narcotrend index will be recorded immediately after the entance to the operating room, at the beginning of induction, 2.5 min, 5 min, 7.5 min, 10 min, 15 min, 20 min, 25 min and 30 min after the beginning of induction, 5 min, 10 min, 15 min, 20 min, 30 min, 45 min and 60 min after the operation.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
For all patients, the induction protocol is midazolam 0.1 mg/kg, sufentanil 0.3 μg/kg, cisatracurium 0.15 mg/kg.
Time frame: Immediately after the entrance to the operating room until until 60 minutes after the operation
Cerebral injury parameters
2 ml blood will be collected immediately after the entrance to the operating room and 60 min after the operation, then SB-100 protein and neuron-specific enolase will be tested by enzyme-linked immunosorbent assay.
Time frame: Immediately after the entrance to the operating room until until 60 minutes after the operation
Length of stay
Time frame: from the date of admission to the day of discharge, expected to 3 days
Score of Minimum Mental State Examination
Score of Minimum Mental State Examination will be examined in preoperative visit, 10 minutes, 45 minutes after the operation
Time frame: 1 day before the operation to 45 minutes after the operation
Verbal Fluency test
Verbal Fluency test will be examined in preoperative visit and 60 minutes after the operation
Time frame: 1 day before the operation to 60 minutes after the operation